Fabrication and evaluation of tri-layered 3D printed scaffold with gradient composition and porosity for osteochondral complex regeneration: An in-vitro study

Summary

The revolution of tissue engineering offers a new alternative regenerative treatment for temporomandibular joint disorders especially when surgical management is required. Severe damage to articular cartilage usually causes lesions for both cartilage and subchondral bone, resulting in osteochondral defects that adversely affect the patients’ masticatory function, speaking, and reducing their quality of life.

The fabrication of mandibular condylar osteochondral scaffolds with structural, mechanical, and biochemical properties to regulate simultaneous cartilage and subchondral bone regeneration is still challenging. A biomimetic tri-layered 3D interconnected scaffold with gradient composition and porosities will be fabricated using liquid crystal display (LCD) based 3D printing technology and will be evaluated regarding its mechanical and biological properties.

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