Study the Relationship between IL-17 and miRNA-146a-5p in Type 1 Diabetes Mellitus.

Summary

Type 1 diabetes mellitus (T1DM) is an autoimmune chronic disease that is characterized by a defective attack of immune cells to the pancreatic β-cells leading to poor insulin production. Secretion of proinflammatory cytokines, especially IL-17, has been implicated in the onset and progression of T1DM in human and animal models. MiRNA are a class of small non-coding RNAs that play a significant role in regulating many diseases including T1DM. Since T1DM has no cure to date, many approaches have been proposed in order to control blood glucose level, minimize inflammation, and manage the disease, however, many serious challenges and complications have been raised towards these approaches. Compared to adult stem cells, exosomes are novel microvesicles that store many excreted potent elements that are substantial for cell-to-cell communication and very cardinal for cells wellness. To the best of our knowledge, this is the first study that aims to explore the role of miRNA-146a-5p in regulating TRAF6/IRAK1/NF-κB signaling inflammatory pathway in T1DM rat model via ameliorating its target inflammatory cytokines, IL-17, with focusing on stem cells derived exosomes as a possible treatment through performing physiological, immunological, molecular, as well as histopathological studies, and confirming these studies by conducting bioinformatics analysis.

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