Nanodiamonds: A Delivery System of an Anticancer Drug for treatment of Lung Cancer

Summary

Nanodiamonds (NDs) are solid nano-entities of stable core and tunable surface. NDs
mediated anticancer drug delivery has been under the focus of scientific community due to their
ability to boost the chemosensitivity of anticancer drugs by sustaining their release and masking
them from the effect of efflux pumps. In the present study proposal, NDs are being employed
for the delivery of a chemotherapeutic drug for the treatment of lung cancer. The safety of
pulmonary delivery of different types of drug-free NDs will primarily be evaluated both in vitro
and in vivo. Then, NDs loading with chemotherapeutic agent and targeting moiety will be
carried out and the resultant nanoparticles will be characterized. The produced nanoparticles
suspension will then be studied for pulmonary delivery either directly by nebulization or by
spray drying with suitable excipients to yield powder for inhalation. In both strategies, the
aerodynamic diameter of the produced aerosol droplets or microspheres will be evaluated.
Finally, a pharmacokinetic study will be carried out to compare the amount of chemotherapeutic
drug delivered to lung in case of intravenous or pulmonary delivery.

Achievements

List of Publications from the Project

Partners

Project Members

• Moustafa Ali

Project Leaders

• Moustafa Ali