Effect of Pentoxifylline on Endothelial Dysfunction in Patients with Acute Coronary Syndrome: A Pilot Study

Summary

Acute Coronary Syndrome (ACS) represents a major cause of morbidity and mortality worldwide and
in Egypt. The risk of a second event and the risk of mortality remains high especially early post-event
which poses a demand for further research. Higher endothelial dysfunction, systemic inflammation,
and oxidative stress where found to be factors related to an increased risk of a recurrent
cardiovascular event in post-ACS patients. Pentoxifylline, as a non-selective inhibitor of
phosphodiesterase (PDE), is an FDA-approved drug for the treatment of intermittent due to peripheral
arterial disease. It was found by more than one study to have anti-inflammatory and anti-oxidant
effects and to impart improvement on markers of endothelial dysfunction. The aim of this study is to
study the effect of using pentoxifylline 400mg three times daily for 2 months on the markers of
endothelial dysfunction, oxidative stress and inflammatory markers in post-ACS patients which if
successful could have the benefit of decreasing the incidence of ACS reoccurrence, prevent
deterioration in the patient's quality of life, and save costs for both the patient and the healthcare
system.

Achievements

The project is still ongoing but the potential achievements are:

- To participate in settling the ongoing research debate regarding the benefecial effects of the drug under research ( pentoxifylline) in Acute Coronary Syndrome patients and whether it can really improve the patient's heightened endothelial dysfunction, inflammatory status and oxidative stress post-disease. The improvement of the aforementioned parameters would reflect on reduced risk of reoccurence of the the disease and thus a better patient quality of life and lower hospital costs on part of the patient and the healthcare system.

- To publish the research in internation Journal of the first quartile rating.

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List of Publications from the Project

https://www.tandfonline.com/doi/full/10.2144/fsoa-2023-0266

Partners

Project Members

Project Leaders

• Asmaa Saeed
• Marwa Adel Ahmed
• Mohamed Ayman Saleh
• Nagwa Ali Sabri