Evaluation of renal damage after PCNL and ESWL using novel RNA Based Biomarkers

Summary

In light of the fact that current researc build up early detection of AKI has produced limited actual clinical applications using various biomarkers such as tissue proteins, nucleic acid, cells or tumor and plasma proteins,we elected to concentrate on a relatively new source of poweful  biomarker, tissue based circular RNA loop

Achievements

Task I:

Project management and consortium completed

-Project management and consortium coordination

-Preparation of the English informed consent

-Preparation of the Arabic informed consent

-Finishing  of the ethical committee requirements for approval 

-Taking the singed approval of the Urology department, Ain Shams university

hospitals to take the samples from the patients 

Task II:

Sample Collection and processing: About 110 samples were collected

1 _60 samples were collected from 20 patients underwent Extracorporeal Shock Wave

Lithotripsy (ESWL)

2_30 samples from 10 Patients underwent percutaneous nephrolithotomy (PCNL).

3.20 samples from 20 healthy controls

Table 1: Sample of cases underwent ESWL and their lab data

List of Publications from the Project

World Journal of Urology https://doi.org/10.1007/s00345-022-03996-3 ORIGINAL ARTICLE

Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy

Ahmed Tawfick1 · Marwa Matboli2 · Sara Shamloul2 · Sara H. A. Agwa3 · Maha Saad4 · Hassan Shaker1 · Mohamed M. Yassin Selim1 · Mohamed S. Salim1 · A. Radwan1 · A. A. Shorbagy1 · Waleed Mousa1

Received: 18 December 2021 / Accepted: 18 March 2022 © The Author(s) 2022

Partners

Project Members

Project Leaders

• Marwa Matboli
• waleed Elsayed Mohamed Mousa