Biomimetic membrane-coated nanoparticles for targeted cardiovascular therapy

Summary

Cardiovascular diseases are the top causes of deaths in Egypt. Ischemic heart disease and stroke account for most mortalities. Nanotechnology is a strong tool to achieve targeted drug delivery and minimize undesirable side effects. We will explore the strong potential of formulation for biodegradable and targeted delivery nanoparticles for this urgent problem. Our project includes i) Development of nanoparticles, from biodegradable and safe polymers, and loading them with anticoagulant and vasodilator drugs. ii) Targeting of prepared nanoparticles using state-of-the-art cell ghosts membrane coating technique, for the first time in Egypt. iii) In vitro assessment of safety of prepared formulations on cardiac cells. iv) In vivo study of the biomimetic membrane-coated nanoparticles on animal models to verify the safety and efficacy of the prepared formulations. Overall, we will implement novel approaches, and endeavor drug-loaded and targeted biomimetic nanoparticles as promising candidates for treatment of cardiovascular diseases. 

Achievements

List of Publications from the Project

Partners

Project Members

• Mina Mehanny

Project Leaders