Socioeconomic level effect on the composition of host-associated microbiome communities and its influence on triggering insulin resistance

Summary

The prevalence of overweight and obesity is greatest amongst certain social standers, contributing to disproportionately higher type 2 diabetes prevalence. Insulin resistance, independent of body mass index, tends to be greater in low socioeconomic status compared to higher socioeconomic status people, yet the mechanisms to explain these differences are not completely understood.

Evidence from diverse sources indicates a significant association between gut microbiota and insulin resistance during the last years. Diet-related obesity promotes insulin resistance through mechanisms independent and dependent on the gut microbiota.

Social and economic factors affect how well and how long we live. Social contexts including living conditions, income, and education, are emerging as fundamental determinants of the microbiome and as possible modifiers of the existing microbiome–health associations across the life course.

Our objective is to determine if gut microbiome profiles differ between different socioeconomic statuses and if so, determine if these social differences persisted when accounting for insulin sensitivity status and finally Diabetes.

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